Bacopa monnieri, makwaara dị ka brahmi na Sanskrit na ụbụrụ tonic na bekee, bụ ahịhịa Ayurvedic a na-ejikarị. Nnyocha sayensị ọhụrụ na-ekwu na egosila na ahịhịa Ayurvedic India Bacopa monnieri na-enyere aka igbochi ọrịa Alzheimer (AD). Nyochaa, nke e bipụtara n'akwụkwọ akụkọ Science Drug Target Insights, bụ ndị otu ndị nyocha Malaysian si Mahadum Taylor dị na United States duziri ma nyochaa mmetụta ahụike nke bacosides, akụkụ bioactive nke osisi ahụ.
N'ịkọwa ihe ọmụmụ abụọ e mere na 2011, ndị nchọpụta ahụ kwuru na bacosides nwere ike ichebe ụbụrụ site na mmebi oxidative na ịda mbà n'obi nke afọ site na ọtụtụ usoro. Dị ka glycoside na-abụghị polar, bacosides nwere ike ịgafe mgbochi ụbụrụ ọbara site na mgbasa ozi na-agafe agafe na lipid dị mfe. Dabere na ọmụmụ ndị gara aga, ndị nchọpụta ahụ kwuru na bacosides nwekwara ike imeziwanye ọrụ ọgụgụ isi n'ihi ihe ndị na-eme ka ọkpụkpụ na-egbuke egbuke.
Uru ahụike ndị ọzọ nkebacosidesgụnyere ichebe neurons site na nsị nke Aβ na-ebute, peptide nke na-arụ ọrụ dị mkpa na pathogenesis nke AD n'ihi na ọ nwere ike ịgbakọta n'ime amyloid fibrils na-adịghị ike. Nyocha a na-ekpughe ngwa ndị dị irè nke Bacopa monnieri na ngwa ngwa nke uche na nke neuroprotective, na phytoconstituents ya nwere ike iji mee ihe maka ịmepụta ọgwụ ọhụrụ. Ọtụtụ osisi omenala nwere ngwakọta mgbagwoju anya nke ogige nwere ụdị ọgwụ dị iche iche na nkà mmụta ọgwụ, karịsịa Bacopa monnieri, nke a na-eji eme ihe. dị ka ọgwụ ọdịnala na mmepe nke ngwaahịa mgbochi ịka nká.
● Uru isii nkeBacopa Monnieri
1.Na-eme ka ebe nchekwa na ọgụgụ isi pụta
Bacopa nwere ọtụtụ uru na-adọrọ adọrọ, mana ọ ga-abụ na a maara ya nke ọma maka ikike ya imeziwanye ebe nchekwa na cognition. Isi usoro nkeBacopana-eme ka ebe nchekwa dịkwuo elu na cognition bụ site na nkwurịta okwu synapti ka mma. Kpọmkwem, ogwu ahụ na-akwalite uto na mmụba nke dendrites, nke na-eme ka mgbaàmà akwara dịkwuo elu.
Cheta na: Dendrites bụ alaka-dị ka akwara cell extensions na-enweta n'ókè na-abata, otú ike ndị a "wires" nke ụjọ usoro nkwurịta okwu na-emecha welie cognition ọrụ.
Nnyocha achọpụtala na Bacoside-A na-akpali mkpụrụ ndụ akwara, na-eme ka synapses na-anabatakwa mkpali akwara na-abata. E gosikwara Bacopa iji kwalite ebe nchekwa na cognition site na ịkpali ọrụ hippocampal site na ịba ụba protein kinase n'ime ahụ, nke na-agbanwe ụzọ dị iche iche cellular.
Ebe ọ bụ na hippocampus dị oke mkpa na ihe fọrọ nke nta ka ọ bụrụ ọrụ niile nke ọgụgụ isi, ndị nchọpụta kwenyere na nke a bụ otu n'ime ụzọ bụ isi nke Bacopa si eme ka ụbụrụ dịkwuo elu.
Ndị ọzọ ọmụmụ egosila na kwa ụbọchị supplementation naBacopa monnieri(na doses nke 300-640 mg kwa ụbọchị) nwere ike imeziwanye:
Ebe nchekwa na-arụ ọrụ
Ebe nchekwa ohere
Ebe nchekwa amaghị ama
Nlebara anya
Ọnụ ọgụgụ mmụta
Nkwado ebe nchekwa
Ọrụ icheta egbuola oge
Ncheta okwu
Ebe nchekwa anya
2.Na-ebelata nchekasị na nchekasị
Ma ọ̀ bụ n'ihe gbasara ego, ọha mmadụ, nke anụ ahụ́, nke uche, ma ọ bụ nke mmetụta uche, nchekasị bụ isi okwu na ndụ ọtụtụ ndị mmadụ. Ugbu a karịa mgbe ọ bụla, ndị mmadụ na-achọ ịgbapụ n'ụzọ ọ bụla dị mkpa, gụnyere ọgwụ ọjọọ na mmanya. Otú ọ dị, ihe ndị dị ka ọgwụ ọjọọ na mmanya na-aba n'anya nwere ike inwe mmetụta dị njọ n'ahụ ike nke uche na nke anụ ahụ mmadụ.
Ị nwere ike ịmasị nke ahụBacopanwere ogologo akụkọ ihe mere eme eji eme ihe dị ka tonic usoro ụjọ iji wepụ mmetụta nke nchekasị, nchekasị, na nchekasị. Nke a bụ n'ihi àgwà adaptogenic nke Bacopa, nke na-eme ka ahụ anyị nwee ike ịnagide, imekọrịta ihe, na mgbake site na nrụgide (uche, anụ ahụ). , na mmetụta uche). Bacopa na-egosipụta njirimara mgbanwe ndị a n'otu akụkụ n'ihi nhazi nke neurotransmitters, mana ahịhịa oge ochie a na-emetụtakwa ọkwa cortisol.
Dị ka ị maara, cortisol bụ isi ihe na-akpata nchekasị n'ahụ. Nchegbu na-adịghị ala ala na ọkwa cortisol dị elu nwere ike imebi ụbụrụ gị. N'ezie, ndị ọkà mmụta sayensị achọpụtala na nrụgide na-adịghị ala ala nwere ike ime ka mgbanwe dị ogologo oge na nhazi ụbụrụ na ọrụ, na-eduga na nkwubi okwu nke ụfọdụ protein na-emebi neurons.
Nchegbu na-adịghị ala ala na-edugakwa na mmebi oxidative nke neurons, nke nwere ike ịkpata nsonaazụ ọjọọ dị iche iche, gụnyere:
Ọnwụ ebe nchekwa
Neuron cell ọnwụ
Ime mkpebi adịghị mma
Atrophy nke ụbụrụ ụbụrụ.
Bacopa monnieri nwere mmetụta dị ike na-ebelata nchekasị, ihe na-egbochi neuroprotective. Ọmụmụ ihe mmadụ edepụtala mmetụta adaptogenic nke Bacopa monnieri, gụnyere ibelata cortisol. Lower cortisol na-eduga ná mbelata mmetụta nke nchekasị, nke nwere ike ọ bụghị nanị imeziwanye ọnọdụ, ma na-amụba elekwasị anya na arụpụtaghị ihe. Ọzọkwa, n'ihi na Bacopa monnieri na-achịkwa dopamine na serotonin, ọ nwere ike ibelata mgbanwe nrụgide na dopamine na serotonin na hippocampus na prefrontal cortex, na-emesiwanye àgwà adaptogenic nke ahịhịa a.
Bacopa monnierina-abawanye mmepụta nke tryptophan hydroxylase (TPH2), enzyme nke dị mkpa maka ọrụ dị iche iche nke usoro ụjọ ahụ, gụnyere njikọ serotonin. Nke kachasị mkpa, bacoside-A, otu n'ime ihe ndị na-arụsi ọrụ ike na Bacopa monnieri, egosila na ọ na-akwalite ọrụ GABA. GABA bụ ihe na-eme ka ahụ dị jụụ, na-egbochi neurotransmitter. Bacopa monnieri nwere ike imeziwanye ọrụ GABA ma belata ọrụ glutamate, nke nwere ike inye aka belata mmetụta nke nchekasị site n'ịbelata ọrụ nke neurons nke nwere ike imebiga ihe ókè. N'ikpeazụ, a na-ebelata mmetụta nke nchekasị na nchekasị, ịrụ ọrụ ụbụrụ na-emeziwanye, na mmetụta ndị ọzọ. -dị mma" vibe.
Oge nzipu: Ọkt-08-2024
