• Gịnị BụPQQ ?
PQQ, aha zuru oke bụ pyrroloquinoline quinone. Dị ka coenzyme Q10, PQQ bụkwa coenzyme nke reductase. N'akụkụ ihe mgbakwunye nri, ọ na-apụtakarị dị ka otu dose (n'ụdị nnu disodium) ma ọ bụ n'ụdị ngwaahịa jikọtara ya na Q10.
Mmepụta eke nke PQQ dị obere. Ọ dị na ala na microorganisms, osisi na anụ ahụ anụmanụ, dị ka tii, natto, kiwifruit, na PQQ dịkwa na anụ ahụ mmadụ.
PQQnwere ọtụtụ ọrụ physiological. Ọ nwere ike ịkwalite mitochondria ọhụrụ n'ime sel (a na-akpọ mitochondria "osisi nhazi ike nke mkpụrụ ndụ"), nke mere na enwere ike ịbawanye ọsọ nke njikọ ike cell. Tụkwasị na nke ahụ, a kwadoro PQQ na ụmụ anụmanụ na ọmụmụ ụmụ mmadụ iji meziwanye ụra, belata ọkwa cholesterol, belata nrụgide oxidative, mee ka ndụ dịkwuo ogologo, kwalite ọrụ ụbụrụ ma belata mbufụt.
N'afọ 2017, otu ndị nyocha nke Prọfesọ Hiroyuki Sasakura na ndị ọzọ sitere na Mahadum Nagoya dị na Japan bipụtara nsonaazụ nyocha ha na akwụkwọ akụkọ "JOURNAL OF CELL SCIENCE". Coenzyme pyrroloquinoline quinone (PQQ) nwere ike ịgbatị ndụ nematodes.
• Gịnị bụ uru ahụike nkePQQ ?
PQQ na-akwalite Mitochondria
N'ime ọmụmụ anụmanụ, ndị nchọpụta na Mahadum California chọpụtara na PQQ nwere ike ịkwalite mmepụta nke mitochondria dị mma. N'ime ọmụmụ ihe a, mgbe ị nwetasịrị PQQ maka izu 8, ọnụ ọgụgụ mitochondria n'ime ahụ mụbara karịa okpukpu abụọ. N'ime ọmụmụ anụmanụ ọzọ, nsonaazụ gosipụtara na mgbochi ahụ belatara nke ukwuu yana ọnụ ọgụgụ mitochondria belatara n'ebughị PQQ. Mgbe agbakwunyere PQQ, a na-eweghachi akara ngosi ndị a ngwa ngwa.
Wepu mbufụt ma gbochie ogbu na nkwonkwo Antioxidant & akwara nchebe
Ọrịa ogbu na nkwonkwo na-enwekarị nsogbu ndị agadi, nke bụkwa ihe dị mkpa na-eduga ná nkwarụ. Nnyocha e mere egosiwo na ọnụ ọgụgụ ndị ọrịa na-arịa ọrịa ogbu na nkwonkwo na-anwụ n'ozuzu ha dị 40% karịa nke ndị mmadụ n'ozuzu. Ya mere, ndị ọkà mmụta sayensị anọwo na-achọsi ike ụzọ ha ga-esi gbochie ma na-ebelata ọrịa ogbu na nkwonkwo. Otu nnyocha e bipụtara na nso nso a n'akwụkwọ akụkọ Inflammation na-egosi naPQQnwere ike ịbụ onye nzọpụta ogbu na nkwonkwo nke ndị nyocha na-achọ.
N'ime ule ụlọ ọgwụ mmadụ, ndị ọkà mmụta sayensị na-eme ka ọnya chondrocyte na tube ule, gbanye PQQ n'ime otu ìgwè nke sel, ma ghara ịgbanye ìgwè nke ọzọ. Nsonaazụ gosiri na ọkwa nke enzymes na-emebi collagen (matrix metalloproteinases) n'ime otu chondrocytes na-etinyeghị PQQ mụbara nke ukwuu.
Site na in vitro na in vivo ọmụmụ, ndị ọkà mmụta sayensị achọpụtala na PQQ nwere ike igbochi ntọhapụ nke ihe ndị na-egbuke egbuke site na mkpụrụ ndụ synovial fibrotic na nkwonkwo, ebe ọ na-egbochi ịmalite ihe ndị na-emepụta ihe na-emepụta ihe na-akpata mbufụt. N'otu oge ahụ, ndị ọkà mmụta sayensị achọpụtawokwa na PQQ nwere ike ibelata ọrụ nke enzymes kpọmkwem (dị ka matrix metalloproteinases), nke na-akụda ụdị 2 collagen na nkwonkwo ma mebie nkwonkwo.
Antioxidant & nchekwa akwara
Nnyocha achọpụtala naPQQnwere mmetụta neuroprotective na oke midbrain neuronal mmebi na ọrịa Parkinson nke rotenone kpatara.
Achọpụtala arụrụ arụ Mitochondrial na nrụgide oxidative bụ isi ihe abụọ kpatara ọrịa Parkinson (PD). Nnyocha egosiwo na PQQ nwere mmetụta antioxidant siri ike ma nwee ike ichebe ischemia cerebral site na iguzogide nrụgide oxidative. A na-ewere nzaghachi nrụgide oxidative dị ka otu n'ime ụzọ kachasị mkpa na-eduga na apoptosis cell. PQQ nwere ike ichebe mkpụrụ ndụ SH-SY5Y site na rotenone (onye na-ahụ maka neurotoxic) na-ebute cytotoxicity. Ndị ọkà mmụta sayensị na-eji PQQ pretreatment iji gbochie rotenone-induced cell apoptosis, weghachi mitochondrial akpụkpọ anụ, na-egbochi mmepụta nke intracellular reactive oxygen ụdị (ROS).
N'ozuzu, nyocha miri emi banyere ọrụ nkePQQna ahụike anụ ahụ nwere ike inyere ụmụ mmadụ aka igbochi ịka nká.
• Enyemaka ỌhụrụPQQNtụ ntụ / Capsules / Mbadamba ụrọ / gummies
Oge nzipu: Ọktoba 26-2024
