Gịnị bụGlabridin?
Glabridin bụ flavonoid ewepụtara na mgbọrọgwụ licorice (Glycyrrhiza glabra) ma nwee ọtụtụ ihe omume ndu yana uru ahụike. A maara glabridin maka ịcha ọcha dị ike, antioxidant na ihe mgbochi mkpali na a na-ejikarị ya na nlekọta anụ ahụ na ịchọ mma.
Glycyrrhiza glabra L. bụ ahịhịa ahịhịa na-eto eto na ndịda Europe, Eshia, na mpaghara Mediterranean. A na-akụ ya na Russia, Spain, Iran na India. Osisi G. glabra dị ihe dị ka mita 1-1.5 n'ogologo, nwere obere akwụkwọ ndụ akwụkwọ ndụ gbara ọchịchịrị, odo, acha anụnụ anụnụ, na violet, na rhizome na-atọ ụtọ.
Glabridin bụ otu n'ime flavonoids bụ isi na Glycyrrhiza glabra. Ọ na-egosi mmetụta siri ike na-egbochi radical radical na cytochrome P450 / NADPH oxidation system, ma nwee ike igbochi radicals free emepụtara n'oge usoro metabolism n'ime ahụ iji gbochie oxidation-sensitive biomacromolecules (obere lipoprotein LDL, DNA) na Mgbidi cell na-emebi site na oxidation free radical. Nke a nwere ike igbochi ma na-agwọ ụfọdụ mgbanwe pathological metụtara free radical oxidation, dị ka atherosclerosis na cell ịka nká. Na mgbakwunye, glabridin nwere mmetụta ụfọdụ nke iwetulata lipids ọbara na ọbara mgbali. Nchọpụta Ịtali ekwenyela na Glabridin nwere mmetụta na-egbochi agụụ, nke nwere ike ibelata abụba na-ebelata ibu. Mgbe ule ugboro ugboro, mmetụta ndị bụ isi bụ ndị a: 1. Ịcha ọcha, na-egbochi melanin; 2. Mmetụta mgbochi mkpali; 3. Mmetụta antioxidant; 4. Antibacterial.
Njirimara anụ ahụ na kemịkalụ nkeGlabridin
1. Chemical Structure
Aha Chemical: Glabridin
Usoro ọgwụ: C20H20O4
Ibu ibu: 324.37 g/mol
Njirimara nhazi: Glabridin bụ ngwakọta flavonoid nwere usoro ọkpụkpụ azụ nke flavonoid. Ọ nwere mgbanaka na-esi ísì ụtọ abụọ (A na B) jikọtara ya na àkwà mmiri carbon atọ nke na-eme mgbanaka pyran mechiri emechi.
2. Njirimara anụ ahụ
Ọdịdị: Glabridin na-apụtakarị dị ka ntụ ntụ kristal na-acha ọcha ma ọ bụ na-acha odo odo.
Solubility:
Mmiri: Ọ na-esichaghị ike na mmiri.
Organic Solvents: Na-agbaze na ihe mgbaze organic dị ka ethanol, methanol, na propylene glycol.
Ebe Na-agbaze: Ihe dị ka 156-158°C (313-316°F).
Isi: Glabridin n'ozuzu enweghị isi dị iche.
3. Njirimara Chemical
Nkwụsi ike: Glabridin kwụsiri ike n'okpuru ọnọdụ nkịtị mana ọ nwere ike wedata mgbe ekpughere ya na ìhè, okpomọkụ, ma ọ bụ ọnọdụ acidic. A na-atụ aro ka ịchekwa ya n'ebe dị jụụ, nke kpọrọ nkụ, na-anọghị na ìhè anyanwụ kpọmkwem.
Mmetụta pH: Glabridin na-enwe mmetụta maka mgbanwe pH ma nwee ike wedata na gburugburu acidic ma ọ bụ nke bụ isi.
Mmeghachi omume: Dị ka flavonoid, glabridin nwere ike nweta mmeghachi omume kemịkalụ na-ejikọta ya na ogige phenolic, dị ka oxidation na conjugation.
Gịnị bụ uru nkeGlabridin?
1. Akpụkpọ anụ na-egbuke egbuke
- Mgbochi nke Tyrosinase: A maara Glabridin nke ọma maka ihe na-eme ka akpụkpọ ahụ ya dị ọcha. Ọ na-egbochi ọrụ nke tyrosinase, enzyme dị mkpa maka mmepụta melanin, si otú ahụ belata nguzobe nke ntụpọ ojii na hyperpigmentation.
- Ọbụna ụda akpụkpọ: Site n'ibelata njikọ nke melanin, glabridin na-enyere aka n'inweta ụda akpụkpọ anụ na ọdịdị na-egbuke egbuke.
2. Njirimara Antioxidant
- Scavenging radical efu: Glabridin nwere akụrụngwa antioxidant siri ike, nke na-enyere aka na-ewepụ radicals efu. Nke a na-ebelata nrụgide oxidative ma gbochie mmebi cellular.
- Mgbochi ịka nká: Ọrụ antioxidant nke glabridin na-enyere aka n'ibelata akara nke ịka nká, dị ka ahịrị dị mma, wrinkles, na ntụpọ afọ, site na ichebe akpụkpọ ahụ pụọ na mmebi oxidative.
3. Mmetụta mgbochi mkpali
- Mbelata nke mbufụt: Glabridin na-egosipụta ihe mgbochi mkpali, nke na-enyere aka ibelata mbufụt akpụkpọ, ọbara ọbara, na ọzịza.
- Mmetụta dị nro: Ọ nwere ike mee ka akpụkpọ ahụ na-agbakasị ahụ belata ma na-aba uru maka ọnọdụ dị ka acne, eczema, na rosacea.
4. Antimicrobial Ọrụ
- Mgbochi nke ọrịa nje: Glabridin egosipụtawo ihe mgbochi nje megide nje bacteria na fungi dị iche iche. Nke a na-eme ka ọ baa uru n'igbochi na ịgwọ ọrịa anụ ahụ.
- Ọgwụgwọ ihe otutu: Njirimara mgbochi ya na mgbochi mkpali na-eme ka glabridin dị irè n'ịgwọ ihe otutu site na ibelata ibu na nje bacteria.
5. Nchekwa UV
- Nchedo foto: Glabridin nwere ike inye ụfọdụ nchebe megide radieshon UV. Ọ na-enyere aka n'ibelata mmebi akpụkpọ ahụ UV kpatara, dị ka ntachu na ịse foto.
- Mmetụta Synergistic: Mgbe ejiri ya na ihe ndị ọzọ na-ekpuchi anyanwụ, glabridin nwere ike ịkwalite mmetụta nchekwa foto niile.
6. Ọgwụgwọ ọnya
- Na-akwalite ọgwụgwọ: Glabridin nwere ike ịkwalite ọgwụgwọ ọnya site na ibelata mbufụt na nrụgide oxidative, yana site n'ịkwalite mmụgharị nke mkpụrụ ndụ akpụkpọ ahụ.
- Mbelata Scar: Ọ nwekwara ike inye aka n'ibelata ọdịdị nke ọnya site n'ịkwalite mmụba akpụkpọ ahụ dị mma.
7. Nlekọta ntutu
- Health Scalp: Glabridin's anti-inflammatory and antimicrobial properties nwere ike ịbara ahụ ike isi ike, na-ebelata dandruff na mgbakasị ahụ.
- Uto ntutu: Site n'ịkwalite ahụike isi isi, glabridin nwekwara ike ịkwalite uto ntutu ka mma.
Kedu ihe bụ ngwa nkeGlabridin?
Ihe ịchọ mma na nlekọta anụ ahụ
1.Skin na-acha ọcha ngwaahịa
- Creams na-acha ọcha na serums: Glabridin bụ ihe dị mkpa n'ọtụtụ akpụkpọ ahụ na-acha ọcha na ngwaahịa na-egbuke egbuke n'ihi ikike ya igbochi ọrụ tyrosinase ma belata mmepụta melanin.
- Ọgwụgwọ ntụpọ: A na-eji ya na usoro iji belata ntụpọ ojii, hyperpigmentation na ụda akpụkpọ ahụ na-enweghị isi.
2.Anti-Aging Products
- Anti-Aging Creams and Lotions: Njirimara antioxidant nke glabridin na-enyere aka n'ibelata ihe ịrịba ama nke ịka nká, dị ka ahịrị dị mma, wrinkles, na ntụpọ afọ.
- Ude anya: A na-etinyekarị ya na ude anya iji belata okirikiri gbara ọchịchịrị na nfụkasị.
3.Anti-Inflammatory and Soothing Products
- Gel na-edozi ahụ na ude: Njirimara mgbochi mkpali nke Glabridin na-eme ka ọ dabara maka ngwaahịa emebere iji mee ka akpụkpọ ahụ na-agbakasị ahụ ma ọ bụ na-ere ọkụ.
- Ọgwụgwọ ihe otutu: Eji ya na ngwaahịa ọgwụgwọ ihe otutu iji belata mbufụt na uto nje.
4.Sun Protection Products
- Sunscreens: Glabridin nwere ike itinye na sunscreens iji nye nchebe ọzọ megide mmebi akpụkpọ anụ UV.
- Nlekọta mgbe anyanwụ gasịrị: A na-eji ngwaahịa na-acha ọkụ ọkụ na-eme ka ọ dị nro ma mezie akpụkpọ anụ ọkụ.
Ngwa ahịa ọgwụ
1. Ọgwụ ọgwụ
- Ude mgbochi mkpali: A na-eji ya na ọgwụ ndị dị n'elu iji gwọọ ọnọdụ akpụkpọ anụ dị ka eczema, psoriasis, na dermatitis.
- Ude Ọnya Ọnya: Agụnyere n'ụdị ezubere iji kwalite ọgwụgwọ ọnya yana ibelata ọnya.
2. Oral Mmeju
-Mgbakwunye Antioxidant: Njirimara antioxidant nke Glabridin na-eme ka ọ bụrụ ihe bara uru na mgbakwunye ọnụ iji belata nrụgide oxidative na ịkwalite ahụike n'ozuzu ya.
- Immune Boosters: A na-eji ya na mgbakwunye emebere iji kwalite ọrụ mgbochi n'ihi ihe mgbochi mkpali na antimicrobial.
Nlekọta ntutu isi
1.Ọgwọ isi
Shampoos na-egbochi daandruff: Glabridin's antimicrobial and anti-inflammatory properties na-eme ka ọ dị irè n'ịgwọ dandruff na mgbakasị ahụ.
- Serums Scalp: A na-eji ya na serum akpụkpọ anụ iji kwalite gburugburu ebe isi awọ dị mma ma nwee ike ịkpalite ntutu isi.
2.Ntutu isi
- Conditioners na ntutu isi: Agụnyere na ngwaahịa nlekọta ntutu iji nye nchebe antioxidant ma melite ahụike ntutu.
Nri na ihe ọṅụṅụ
Nri arụrụ arụ
- Ihe ọṅụṅụ ahụike: Glabridin nwere ike ịgbakwunye na mmanya ahụike yana ihe ọṅụṅụ na-arụ ọrụ iji nye uru antioxidant na mgbochi mkpali.
- Ogwe nri na-edozi ahụ: A na-eji ya n'ụlọ mmanya na nri nri iji kwalite ahụike na ọdịmma zuru oke.
Nnyocha na mmepe
Nnyocha biomedical
- Nnyocha ọrịa kansa: A na-amụ Glabridin maka ihe nwere ike igbochi ọrịa kansa, gụnyere ike ya igbochi uto mkpụrụ ndụ kansa na ịkpata apoptosis.
- Nnyocha ọrịa na-adịghị ala ala: Achọpụtara maka uru ọ nwere n'ịchịkwa ọrịa ndị na-adịghị ala ala dịka ọrịa shuga na ọrịa obi n'ihi mgbochi mkpali na antioxidant Njirimara.
Ajụjụ ndị emetụtara ị nwere ike ịmasị gị:
Ogologo oge ole ka ọ na-ewe maka mmịpụta licoriceglabridinime ka akpụkpọ ahụ dị nro?
Oge ọ na-ewe maka mpempe akwụkwọ licorice nwere glabridin iji mee ka akpụkpọ ahụ dịkwuo ọkụ nwere ike ịdịgasị iche dabere n'ọtụtụ ihe, gụnyere ntinye nke glabridin na ngwaahịa ahụ, ugboro ngwa ngwa, ụdị akpụkpọ ahụ nke onye ahụ, na ịdị njọ nke hyperpigmentation. Nke a bụ ụfọdụ ntuziaka na nleba anya:
1. Ogologo oge a na-ahụkarị
- Nsonaazụ mbụ: Ụfọdụ ndị ọrụ nwere ike ịmalite ịhụ mmelite mbụ na ụda anụ ahụ yana mbelata hyperpigmentation n'ime izu 2 ruo 4 nke iji ya eme ihe.
- Nsonaazụ dị ịrịba ama: mmetụta ndị a na-ahụ anya na nke pụtara ìhè na-emekarị mgbe izu 8 ruo 12 nke ngwa ngwa gasịrị.
2. Ihe Na-emetụta Ịrụ Ọrụ
Ntinye uche nke Glabridin
- Ntụkwasị obi dị elu: Ngwaahịa nwere mkpokọta glabridin dị elu (dịka, 0.5% ruo 1%) nwere ike iwepụta nsonaazụ ngwa ngwa na karịa.
- Ntụkwasị obi dị ala: Ngwaahịa nwere mkpokọta dị ala nwere ike iwe ogologo oge iji gosipụta mmetụta a na-ahụ anya.
Ugboro nke ngwa
- Ojiji kwa ụbọchị: Itinye ngwaahịa ahụ otu ugboro ma ọ bụ ugboro abụọ kwa ụbọchị, dị ka akwadoro, nwere ike ịkwalite ịdị irè yana mee ka nsonaazụ ya dị ngwa.
- Ojiji na-ekwekọghị ekwekọ: Ngwa na-adịghị agbanwe agbanwe nwere ike igbu oge mmetụta a na-ahụ anya ma belata nrụpụta n'ozuzu ya.
Ụdị akpụkpọ ahụ na ọnọdụ
- Ụdị akpụkpọ ahụ: Ndị nwere ụda akpụkpọ ahụ dị nro nwere ike ịhụ nsonaazụ ngwa ngwa karịa ndị nwere ụda akpụkpọ ahụ.
- Ogo nke hyperpigmentation: hyperpigmentation dị nro nwere ike ịzaghachi ngwa ngwa na ọgwụgwọ, ebe ikpe ndị ka njọ nwere ike iwe ogologo oge iji gosipụta ọganihu.
3. Usoro nlekọta anụ ahụ na-agbakwunyere
- Nchedo anwụ: Iji mkpuchi anwụ kwa ụbọchị dị oke mkpa mgbe ị na-eji ngwaahịa na-amụba akpụkpọ ahụ iji gbochie pigmenti ọzọ ma chebe akpụkpọ ahụ pụọ na mmebi UV.
- Moisturization: Idobe akpụkpọ ahụ nke ọma nwere ike ime ka nnabata na ịdị irè nke ngwaahịa nwere glabridin dị.
- Mpụpụ: Mpụpụ mgbe niile nwere ike inye aka wepụ mkpụrụ ndụ akpụkpọ ahụ nwụrụ anwụ ma kwalite ntinye nke ihe ndị na-arụ ọrụ, nwere ike ime ka nsonaazụ dị ngwa.
4. Nnyocha ụlọ ọgwụ na ihe akaebe
- Ọmụmụ ụlọ ọgwụ: Ụfọdụ ọmụmụ ụlọ ọgwụ egosila na glabridin nwere ike belata hyperpigmentation nke ukwuu ma melite ụda anụ ahụ n'ime izu 8 ruo 12 nke iji ya eme ihe mgbe niile.
- Akaebe onye ọrụ: Ọtụtụ ndị ọrụ na-akọ na ha hụrụ mmelite pụtara ìhè na ụda anụ ahụ yana mbelata ntụpọ gbara ọchịchịrị n'ime izu ole na ole ruo ọnwa ole na ole nke ngwa mgbe niile.
Gịnị bụ mmetụta nkeglabridin?
Glabridin nwere ọrụ dị iche iche nke ndụ yana uru ahụike, mana n'ọnọdụ ụfọdụ, iji ngwaahịa nwere glabridin nwere ike ịkpata mmetụta ụfọdụ. Ndị na-esonụ bụ mmetụta ndị nwere ike ime na ịkpachara anya maka glabridin:
1. Mgbakasị akpụkpọ ahụ na ihe nfụkasị ahụns
Iwe mgbakasị ahụ
- Mgbaàmà: nwere ike ịgụnye ọbara ọbara, ọzịza, itching, nrịanrịa, ma ọ bụ mmetụta ọkụ.
- Ihe kpatara: Mmetụta anụ ahụ na glabridin ma ọ bụ ihe ndị ọzọ dị na ngwaahịa ahụ nwere ike ịkpata obere mgbakasị anụ ahụ.
Mmeghachi omume nfụkasị ahụ
- Mgbaàmà: nwere ike ịgụnye ọkụ ọkụ, erythema, ọzịza, ma ọ bụ itching siri ike.
- Ihe kpatara: Allergy na glabridin ma ọ bụ ihe ndị ọzọ dị na ngwaahịa ahụ, nke nwere ike ịkpalite mmeghachi ahụ nfụkasị ahụ.
2. Photosensitivity
- Mmụba mmetụta nke ìhè anyanwụ: glabridin nwere ike ịbawanye mmetụta anụ ahụ na ìhè anyanwụ, na-eduga na ntachu ma ọ bụ dermatitis photosensitivity.
- Mgbochi: Mgbe ị na-eji ngwaahịa nwere glabridin, a na-atụ aro ka ị na-eji ihe mkpuchi anwụ sara mbara ma zere ikpughe ogologo oge na anyanwụ.
3. Mmetụta Hormonal
Omume Hormonal nwere ike ime: Ọ bụ ezie na glabridin bu n'uche maka iji ya eme ihe, ụfọdụ akụkụ nke licorice (dị ka glycyrrhizic acid) maara na ọ nwere mmetụta steroid nke nwere ike imetụta nguzozi nke hormone.
- Ntụle: Mgbe ị na-eji ngwaahịa nwere glabridin n'ọtụtụ buru ibu ruo ogologo oge, ị kwesịrị ịṅa ntị iji hụ ma enwere ihe mgbaàmà nke ndakpọ nke hormonal.
4. Mmekọrịta na ihe ndị ọzọ na-ahụ maka nlekọta anụ ahụ
- Mmekọrịta nwere ike ime: glabridin nwere ike iji ihe ndị ọzọ na-arụ ọrụ na-emekọrịta ihe (dịka vitamin C, retinol, wdg), na-emetụta irè ya ma ọ bụ na-abawanye ohere nke mmetụta ndị ọzọ.
- Nkwanye: Mgbe ị na-eji ngwaahịa nwere glabridin, a na-atụ aro ka ị zere iji ihe ndị ọzọ siri ike na-arụ ọrụ n'otu oge ma ọ bụ kpọtụrụ onye na-ahụ maka akpụkpọ anụ tupu eji ya.
5. Mmetụta sistemu
- Mmachi nwere oke:glabridina na-ejikarị eme ihe maka mpụga ma nwee obere absorption nke sistemu, yabụ mmetụta nke sistemu anaghị adịkarị.
- Akpachara anya: Ọ bụrụ na ị na-enweta ahụ erughị ala ma ọ bụ mmeghachi omume na-adịghị mma, ị kwesịrị ịkwụsị iji ya ozugbo wee kpọtụrụ dọkịta gị.
6. Ime na inye ara
- Nchegbu nchekwa: Enwere data dị ntakịrị ugbu a maka nchekwa nke glabridin n'ime ụmụ nwanyị dị ime na ndị na-enye nwa ara.
- Nkwanye: Ụmụ nwanyị dị ime na ndị nọọsụ kwesịrị ịkpọtụrụ dọkịta ha tupu ha ejiri ngwaahịa nwere glabridin.
Oge nzipu: Sep-21-2024
