Gịnị bụAzelaic acid?
Azelaic acid bụ dicarboxylic acid nke na-eme n'okike nke a na-ejikarị na nlekọta anụ ahụ yana ịgwọ ọnọdụ akpụkpọ ahụ dị iche iche. Ọ nwere antibacterial, mgbochi mkpali na keratin na-achịkwa ihe na-achịkwa ma na-ejikarị agwọ nsogbu akpụkpọ anụ dị ka ihe otutu, rosacea na hyperpigmentation.
Njirimara anụ ahụ na kemịkalụ nke Azelaic Acid
1. Chemical Structure na Njirimara
Ọdịdị Chemical
Aha Chemical: Azelaic Acid
Usoro ọgwụ: C9H16O4
Ibu ibu: 188.22 g/mol
Nhazi: Azelaic acid bụ dicarboxylic acid nke nwere eriri kwụ ọtọ.
2.Ngwongwo anụ ahụ
Ọdịdị: Azelaic acid na-apụtakarị dị ka ntụ ntụ ọcha crystalline.
Solubility: Ọ na-agbaze ntakịrị na mmiri mana ọ na-agbaze na ihe mgbaze organic dị ka ethanol na propylene glycol.
Ebe Na-agbaze: Ihe dị ka 106-108°C (223-226°F).
3. Usoro nke Action
Antibacterial: Azelaic acid na-egbochi uto nke nje bacteria, karịsịa Propionibacterium acnes, nke bụ isi ihe na-enye aka na ihe otutu.
Mgbochi mgbochi: Ọ na-ebelata mbufụt site na igbochi mmepụta nke cytokines pro-inflammatory.
Keratinization Regulation: Azelaic acid na-enyere aka normalize mwụsị nke anụ ahụ nwụrụ anwụ, na-egbochi pores mechiri emechi na nguzobe nke comedones.
Mgbochi Tyrosinase: Ọ na-egbochi enzyme tyrosinase, nke na-etinye aka na mmepụta melanin, si otú ahụ na-enyere aka belata hyperpigmentation na melasma.
Gịnị bụ uru nkeAzelaic acid?
Azelaic acid bụ dicarboxylic acid dị iche iche nke a na-ejikarị na nlekọta anụ ahụ na ọgwụgwọ nke nsogbu akpụkpọ ahụ dị iche iche. Nke a bụ isi uru nke azelaic acid:
1. Na-emeso ihe otutu
- Mmetụta nje: Azelaic acid nwere ike igbochi uto nke Propionibacterium acnes na Staphylococcus aureus, nke bụ isi nje bacteria na-akpata ihe otutu.
- Mmetụta mgbochi mkpali: Ọ nwere ike ibelata nzaghachi mkpali nke akpụkpọ ahụ ma wepụ ọbara ọbara, ọzịza na mgbu.
- Keratin Regulating: Azelaic acid na-enyere aka normalize mwụsị nke mkpụrụ ndụ akpụkpọ ahụ nwụrụ anwụ, na-egbochi pores mechiri emechi na nhazi nke otutu.
2. Ọgwụgwọ Rosacea
- Belata ọbara ọbara: Azelaic acid na-ebelata ọbara ọbara na mbufụt metụtara rosacea.
- Mmetụta Antibacterial: Ọ na-egbochi uto nke nje bacteria metụtara rosacea ma na-ebelata ihe ize ndụ nke ọrịa akpụkpọ ahụ.
3. Mma pigmentation
- Mmetụta na-acha ọcha: Azelaic acid na-enyere aka ibelata pigmentation na chloasma site na igbochi ọrụ tyrosinase na ibelata mmepụta melanin.
- Ọbụna ụda akpụkpọ ahụ: iji oge niile na-eme ka ụda akpụkpọ ahụ dịkwuo ọbụna karị, na-ebelata ntụpọ gbara ọchịchịrị na agba na-enweghị isi.
4. Mmetụta antioxidant
- Neutralizing Free Radicals: Azelaic acid nwere ihe antioxidant nke na-ewepụ radicals efu ma belata nrụgide oxidative mebiri akpụkpọ ahụ.
- Mgbochi ịka nká: Site na ibelata mmebi radical n'efu, Azelaic acid na-enyere aka ịka nká ngwa ngwa ma belata ọdịdị nke ahịrị dị mma na wrinkles.
5. Ọgwụgwọ nke Post-inflammatory pigmentation (PIH)
- Belata pigmentation: Azelaic acid na-emeso hyperpigmentation post-inflammatory nke ọma, nke na-emekarị mgbe otutu ma ọ bụ ọnọdụ akpụkpọ anụ ndị ọzọ na-akpasu iwe.
- Kwalite nrụzi akpụkpọ ahụ: Ọ na-akwalite mmeghari na nrụzi nke mkpụrụ ndụ akpụkpọ ahụ ma na-eme ka mbelata nke pigmenti ngwa ngwa.
6. Kwesịrị ekwesị maka akpụkpọ anụ
- Dị nro na nke na-adịghị ewe iwe: Azelaic acid na-anabatakarị nke ọma ma dabara maka ụdị anụ ahụ nwere mmetụta.
- Noncomedogenic: Ọ naghị egbochi pores ma dị mma maka akpụkpọ ahụ nwere otutu.
7. Na-agwọ ọrịa anụ ahụ ndị ọzọ
- Keratosis Pilaris: Azelaic acid nwere ike inye aka belata akpụkpọ anụ ahụ siri ike, nke jikọtara ya na Keratosis Pilaris.
- Ọrịa akpụkpọ anụ ndị ọzọ na-afụ ụfụ: Ọ nwekwara mmetụta ọgwụgwọ ụfọdụ na ọrịa anụ ahụ ndị ọzọ na-egbuke egbuke dị ka eczema na psoriasis.
Kedu ihe bụ ngwa nkeAzelaic acid?
1. Na-emeso ihe otutu: Topical preparations
-Acne Creams na Gel: A na-ejikarị Azelaic acid eme nkwadebe n'elu iji gwọọ ihe otutu na-adịghị ala ala. Ọ na-enyere aka belata ọnụ ọgụgụ nke ọnya ihe otutu ma gbochie ịmepụta nke ọhụrụ.
Usoro ọgwụgwọ ngwakọta: A na-ejikarị ya na ọgwụgwọ otutu ndị ọzọ dị ka benzoyl peroxide ma ọ bụ retinoic acid iji welie irè.
2. Ọgwụgwọ nke Rosacea: nkwadebe mgbochi mkpali
- Rosacea Creams na Gels: Azelaic acid na-ebelata ọbara ọbara na mbufụt metụtara rosacea nke ọma ma na-ejikarị ya eme ihe na nkwadebe n'elu nke ezubere iche maka rosacea.
- Nlekọta ogologo oge: Kwesịrị ekwesị maka nlekọta ogologo oge nke rosacea, na-enyere aka ịnọgide na-enwe ọnọdụ akpụkpọ anụ.
3. Meziwanye pigmenti: Ngwaahịa na-acha ọcha
- Creams na Serum na-egbuke egbuke: Azelaic acid na-enyere aka ibelata pigmenti na melasma site na igbochi ọrụ tyrosinase na ibelata mmepụta melanin.
- Ọbụna ụda akpụkpọ ahụ: iji oge niile na-eme ka ụda akpụkpọ ahụ dịkwuo ọbụna karị, na-ebelata ntụpọ gbara ọchịchịrị na agba na-enweghị isi.
4. Antioxidant na mgbochi ịka nká: Antioxidant ngwaahịa nlekọta anụ ahụs
- Anti-Aging Creams na Serums: Njirimara antioxidant nke Azelaic acid na-eme ka ọ bụrụ ihe dị mkpa na ngwaahịa nlekọta anụ ahụ na-egbochi ịka nká, na-enyere aka belata mmebi nke radical n'efu na akpụkpọ ahụ ma na-ebelata ịka nká.
- Nlekọta anụ ahụ kwa ụbọchị: Kwesịrị ekwesị maka nlekọta anụ ahụ kwa ụbọchị, na-enye nchebe antioxidant na idobe ahụ ike.
5. Ọgwụgwọ nke Post-Inflammatory Pigmentation (PIH): Ngwaahịa Mmezi Pigmentation
- Ndozi Creams na Serums: Azelaic acid dị irè n'ịgwọ hyperpigmentation post-inflammatory ma na-ejikarị emezi ude na serums iji nyere aka mee ka mfu nke hyperpigmentation dịkwuo elu.
- Mmezi akpụkpọ ahụ: kwalite mmeghari na nrụzi nke mkpụrụ ndụ akpụkpọ ahụ ma mee ka mbelata nke pigmenti dị ngwa ngwa.
6. Na-agwọ ọrịa anụ ahụ ndị ọzọ
Keratosis pilaris
Ngwaahịa na-edozi keratin: Azelaic acid nwere ike inye aka belata akpụkpọ ahụ siri ike, nke na-ejikọta ya na keratosis pilaris ma na-ejikarị ya na ngwaahịa na-edozi keratin.
- Skin Smoothing: Na-akwalite ire ụtọ na ịdị nro, na-eme ka ọdịdị akpụkpọ ahụ dịkwuo mma.
Ọrịa akpụkpọ anụ ndị ọzọ na-egbu egbu
- Eczema na Psoriasis: Azelaic acid nwekwara ụfọdụ mmetụta ọgwụgwọ na ọrịa akpụkpọ anụ ndị ọzọ na-akpasu iwe dị ka eczema na psoriasis, a na-ejikarị ya eme ihe n'usoro nkwadebe.
7. Nlekọta akpụkpọ anụ: Mgbochi na-egbu egbu na ngwaahịa nje
- Ngwaahịa Nlekọta akpụkpọ anụ: Azelaic acid na-egbochi mkpali na ihe na-egbu egbu na-eme ka ọ dị mma maka ojiji na ngwaahịa nlekọta akpụkpọ anụ iji nyere aka belata mbufụt na ọrịa.
- ahụ ike isi: na-akwalite ahụ ike isi ma na-ebelata dandruff na itching.
Ajụjụ ndị emetụtara ị nwere ike ịmasị gị:
Ọ na-emeazelaic acidnwere mmetụta ọjọọ?
Azelaic acid nwere ike inwe mmetụta dị n'akụkụ, ọ bụ ezie na ọtụtụ ndị mmadụ na-anabata ya nke ọma. Mmetụta ndị dị na ya na-adịkarị nwayọọ ma na-ebelata ka iji ya na-aga n'ihu. Nke a bụ ụfọdụ mmetụta na echiche nwere ike ime:
1. Mmetụta Na-emekarị
Iwe mgbakasị ahụ
- Mgbaàmà: mgbakasị ahụ dị nro, ọbara ọbara, itching, ma ọ bụ mmetụta ọkụ na saịtị ngwa.
- Nlekọta: Mgbaàmà ndị a na-ebelatakarị ka akpụkpọ ahụ gị na-agbanwe na ọgwụgwọ ahụ. Ọ bụrụ na iwe na-aga n'ihu, ịnwere ike ibelata ugboro ngwa ngwa ma ọ bụ kpọtụrụ onye na-ahụ maka ahụike.
Akọrọ na ekpepụsị
- Mgbaàmà: akpịrị ịkpọ nkụ, mkpụkpọ akpụ, ma ọ bụ ihichapụ akpụkpọ ahụ.
- Nlekọta: Jiri mmiri mmiri dị nro mee ka ọ dị jụụ ma nọgide na-enwe mmiri mmiri.
2. Mmetụta Na-akpata Na-adịkarịghị
Mmeghachi omume hypersensitivity
- Mgbaàmà: oke itching, ọkụ ọkụ, ọzịza, ma ọ bụ hives.
- Njikwa: Kwụsị iji ozugbo wee kpọtụrụ onye na-ahụ maka ahụike ma ọ bụrụ na ị nweta akara ọ bụla nke mmeghachi ahụ nfụkasị ahụ.
Mmụba nke mmetụta anyanwụ
- Mgbaàmà: Mmụba mmetụta nke ìhè anyanwụ, na-eduga n'ọkụ anwụ ma ọ bụ mmebi anyanwụ.
- Nlekọta: Jiri ihe mkpuchi anwụ nke sara mbara kwa ụbọchị ma zere ikpughe anyanwụ ogologo oge.
3. Mmetụta dị ụkọ
Mmeghachi omume akpụkpọ ahụ siri ike
- Mgbaàmà: oke ọbara ọbara, ọnya, ma ọ bụ bee siri ike.
- Njikwa: Kwụsị iji ma chọọ ndụmọdụ ahụike ma ọ bụrụ na ị nweta mmeghachi omume anụ ahụ siri ike.
4. Akpachara anya na nlebara anya
Nnwale patch
- Nkwanye: Tupu iji azelaic acid, mee nyocha patch na obere akụkụ akpụkpọ ahụ iji lelee mmeghachi omume ọjọọ ọ bụla.
Okwu Mmalite nke nta nke nta
- Nkwanye: Ọ bụrụ na ị bụ onye ọhụrụ na azelaic acid, malite na ntinye uche dị ala wee jiri nwayọọ nwayọọ mụbaa ugboro ngwa iji mee ka akpụkpọ ahụ gị gbanwee.
Ndụmọdụ
- Nkwanye: Kpọtụrụ onye na-ahụ maka anụ ahụ ma ọ bụ onye na-ahụ maka ahụike tupu ịmalite azelaic acid, ọkachasị ma ọ bụrụ na ị nwere akpụkpọ anụ ahụ ma ọ bụ na-eji ihe nlekọta anụ ahụ ndị ọzọ na-arụ ọrụ.
5. Ndị mmadụ pụrụ iche
Ime na inye ara
- Nchekwa: A na-ewere Azelaic acid dị mma maka ojiji n'oge ime na ị na-enye nwa ara, mana ọ kacha mma mgbe niile ịkpọtụrụ onye nlekọta ahụike tupu ịmalite ọgwụgwọ ọhụrụ ọ bụla.
Akpụkpọ ahụ nwere mmetụta
- Ntụle: Ndị nwere akpụkpọ ahụ dị nro kwesịrị iji azelaic acid na-akpachara anya ma nwee ike irite uru na usoro emebere maka akpụkpọ ahụ dị nro.
Ogologo oge ole ka ọ na-ewe iji hụ nsonaazụazelaic acid?
Oge ọ na-ewe iji hụ nsonaazụ sitere na acid azelaic nwere ike ịdịgasị iche, mana a na-ahụkarị mmelite mbụ n'ime izu 2 ruo 4 maka otutu, izu 4 ruo 6 maka rosacea, yana izu 4 ruo 8 maka hyperpigmentation na melasma. Nsonaazụ dị ịrịba ama karịa na-emekarị mgbe izu 8 ruo 12 nke ojiji na-agbanwe agbanwe. Ihe ndị dị ka ntinye nke azelaic acid, ugboro ole a na-etinye ngwa ngwa, njirimara akpụkpọ ahụ nke onye ọ bụla, na ịdị njọ nke ọnọdụ a na-agwọ nwere ike imetụta ịdị irè na ọsọ nke nsonaazụ. Iji ya eme ihe mgbe niile na nke na-agbanwe agbanwe, yana usoro nlekọta anụ ahụ agbakwunyere, nwere ike inye aka nweta nsonaazụ kacha mma.
Ihe na-emetụta nsonaazụ
Ntinye nke Azelaic acid
Ntụkwasị obi dị elu: Ngwaahịa nwere njupụta dị elu nke azelaic acid (dịka, 15% ruo 20%) nwere ike iwepụta nsonaazụ ngwa ngwa yana karịa.
Ntụkwasị obi dị ala: Ngwaahịa nwere mkpokọta dị ala nwere ike iwe ogologo oge iji gosipụta mmetụta a na-ahụ anya.
Ugboro nke ngwa
Ojiji na-agbanwe agbanwe: Itinye azelaic acid dị ka a gwara ya, na-emekarị otu ugboro ma ọ bụ ugboro abụọ kwa ụbọchị, nwere ike ịkwalite ịdị irè ma mee ka nsonaazụ ya dịkwuo elu.
Ojiji na-ekwekọghị ekwekọ: Ngwa oge niile nwere ike igbu oge mmetụta a na-ahụ anya ma belata nrụpụta n'ozuzu ya.
Njirimara akpụkpọ anụ nke onye
Ụdị akpụkpọ ahụ: Ụdị akpụkpọ ahụ na ọnọdụ onye ọ bụla nwere ike imetụta otu esi ahụ ngwa ngwa nsonaazụ. Dịka ọmụmaatụ, ndị nwere ụda akpụkpọ ahụ dị nro nwere ike ịhụ nsonaazụ ngwa ngwa karịa ndị nwere ụda akpụkpọ ahụ gbara ọchịchịrị.
Ogo nke ọnọdụ: Oke ọnọdụ akpụkpọ ahụ a na-agwọ nwekwara ike imetụta oge ọ na-ewe iji hụ nsonaazụ. Ọnọdụ dị nro nwere ike ịza ngwa ngwa karịa ikpe ndị ka njọ.
Kedu mgbe ị ga-eji azelaic acid, ụtụtụ ma ọ bụ abalị?
Enwere ike iji Azelaic acid ma n'ụtụtụ ma n'abalị, dabere na usoro nlekọta anụ ahụ gị na mkpa ụfọdụ. Ọ bụrụ na ejiri ya n'ụtụtụ, na-esochi mkpuchi anwụ mgbe niile iji chebe akpụkpọ gị pụọ na mmebi UV. Iji ya eme ihe n'abalị nwere ike ịkwalite nrụzi akpụkpọ ahụ ma belata mmekọrịta ya na ihe ndị ọzọ na-arụ ọrụ. Maka uru kachasị, ụfọdụ ndị na-ahọrọ iji azelaic acid ma ụtụtụ ma n'abalị, mana ọ dị mkpa iji nyochaa nzaghachi akpụkpọ gị ma gbanwee ya. Na-etinye azelaic acid mgbe niile mgbe ịsachara na tupu mmiri ara ehi, ma tụlee otú o si daba na usoro nlekọta anụ ahụ gị n'ozuzu iji nweta nsonaazụ kacha mma.
Gịnị na-agaghị mix naazelaic acid?
Azelaic acid bụ ihe eji elekọta anụ ahụ na-anabata ya nke ọma, mana ọ dị mkpa iburu n'uche ka o si emekọrịta ihe na ihe ndị ọzọ na-arụ ọrụ na usoro nlekọta anụ ahụ gị. Ịgwakọta ụfọdụ ihe ndị na-emepụta ihe nwere ike ibute iwe, ibelata nrụpụta ọrụ, ma ọ bụ mmetụta ndị ọzọ achọghị. Nke a bụ ụfọdụ ntuziaka maka ihe agaghị agwakọta na azelaic acid:
1. Ike Exfoliants
Alfa Hydroxy Acids (AHA)
- Ọmụmaatụ: Glycolic acid, lactic acid, mandelic acid.
- Ihe kpatara ya: Ijikọta azelaic acid na AHA siri ike nwere ike ime ka iwe iwe, ọbara ọbara, na peeling dịkwuo elu. Ha abụọ bụ exfoliants, na iji ha ọnụ nwere ike ịdị njọ maka akpụkpọ ahụ.
Beta Hydroxy Acids (BHA)
- Ọmụmaatụ: salicylic acid.
- Ihe kpatara: Dị ka AHA, BHA bụkwa exfoliants. Iji ha na-ejikọta ya na azelaic acid nwere ike iduga n'ife oke na anụ ahụ.
2. Retinoids
- Ọmụmaatụ: Retinol, Retinaldehyde, Tretinoin, Adapalene.
- Ihe kpatara ya: Retinoids bụ ihe ndị nwere ike ịkpata nkụ, peeling, na mgbakasị ahụ, karịsịa mgbe ewepụtara ya na mbụ. Ijikọta ha na azelaic acid nwere ike ime ka mmetụta ndị a dịkwuo njọ.
3. Benzoyl peroxidee
Ihe kpatara ya
- mgbakasị ahụ: Benzoyl peroxide bụ ihe mgbochi siri ike na-alụ ọgụ nke nwere ike ịkpata nkụ na mgbakasị ahụ. Iji ya n'akụkụ azelaic acid nwere ike ịbawanye ohere nke mgbakasị ahụ akpụkpọ ahụ.
- Mbelata arụmọrụ: Benzoyl peroxide nwekwara ike oxidize ihe ndị ọzọ na-arụ ọrụ, nwere ike ibelata arụmọrụ ha.
4. Vitamin C (ascorbic acid)
Ihe kpatara ya
- ọkwa pH: Vitamin C (ascorbic acid) chọrọ pH dị ala ka ọ dị irè, ebe azelaic acid na-arụ ọrụ kacha mma na pH dịtụ elu. Iji ha ọnụ nwere ike imebi ịdị mma nke ihe abụọ ahụ.
- Iwe iwe: Ijikọta ihe abụọ a nwere ike nwere ike ime ka iwe ahụ dịkwuo elu, karịsịa maka akpụkpọ anụ.
5. Niacinamide
Ihe kpatara ya
- Mmekọrịta nwere ike ime: Ọ bụ ezie na niacinamide na-anabatakarị nke ọma ma nwee ike iji ya na ọtụtụ ihe na-arụ ọrụ, ụfọdụ ndị nwere ike inwe mgbakasị mgbe ị na-ejikọta ya na azelaic acid. Nke a abụghị iwu zuru ụwa ọnụ, mana ọ bụ ihe kwesịrị ịma.
6. Ọrụ ndị ọzọ nwere ike
Ihe atụ
- Hydroquinone, Kojic Acid na ihe ndị ọzọ na-eme ka akpụkpọ ahụ dịkwuo mma.
- Ihe kpatara ya: Ijikọta ọtụtụ ihe na-arụ ọrụ ike iji na-agwọ hyperpigmentation nwere ike ịbawanye ihe ize ndụ nke iwe na nwere ike ọ gaghị eme ka ọ dịkwuo mma.
Otu esi etinyeAzelaic acidN'enweghị nsogbu:
Ọzọ Use
- Strategy: Ọ bụrụ na ịchọrọ iji azelaic acid n'akụkụ ndị ọzọ na-arụsi ọrụ ike, tụlee ịgbanwe ojiji ha. Dịka ọmụmaatụ, jiri azelaic acid n'ụtụtụ yana retinoids ma ọ bụ AHA / BHA n'abalị.
Nnwale patch
- Nkwanye: Na-eme ule patch mgbe niile mgbe ị na-ewebata ihe ọhụrụ na-arụ ọrụ na usoro gị iji lelee mmeghachi omume ọjọọ ọ bụla.
Bido nwayọ
- Strategy: Webata azelaic acid nke nta nke nta, na-amalite site na itinye uche dị ala yana ịba ụba ugboro ka akpụkpọ gị na-ewulite ndidi.
Kpọtụrụ onye dọkịta gbasara anụ ahụ
- Nkwanye: Ọ bụrụ na ịmaghị maka otu esi etinye azelaic acid n'ime usoro gị, kpọtụrụ onye na-ahụ maka anụ ahụ maka ndụmọdụ ahaziri onwe gị.
Oge nzipu: Sep-21-2024